Diving into the dark side of ependymoma
Mariella Filbin, MD, PhD, a neuro-oncologist at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, is driven by a desire to find new therapies for some of the hardest-to-treat pediatric brain tumors. At the core of her work is an effort to uncover the events that shape tumor development. Key takeaways:· Aggressive ependymoma tumors are stuck ... Read More
Internet searches provide real-time estimate of Lyme disease risk
Lyme disease season is well underway. How much of a risk do we face for this tick-borne illness? A new method dubbed Lymelight, developed by researchers at Boston Children’s Hospital and Google, can accurately estimate Lyme disease risk in real time, down to the county level. Historically, estimates of Lyme disease have been based on ... Read More
New drug pathway linked with tuberous sclerosis
Tuberous sclerosis complex (TSC) is a neurological disorder causing non-cancerous tumors, called cortical tubers, to grow throughout the brain and body, as well as other conditions like epilepsy and autism. While medications are used to treat some of the manifestations of the disease, safe and more effective treatments targeting disease at a fundamental level are ... Read More
Boston Children’s Hospital leads national study on pediatric COVID-19 and MIS-C
Why are children largely spared from COVID-19 — and why do a few become extremely sick? To find out, Boston Children’s Hospital launched a national study in April to perform real-time surveillance at more than 35 U.S. children’s hospitals. In May, when multi-system inflammatory syndrome in children (MIS-C) began appearing, that still-mysterious condition was added ... Read More
Getting to a COVID-19 vaccine as fast and as safely as possible
The novel coronavirus is not expected to disappear anytime soon. With physical distancing, virus testing, contact tracing, and potentially new therapeutics, we may be able to keep it partially at bay. But many eyes are looking toward a COVID-19 vaccine, and scientists are feeling the urgency. Key takeaways. Work is moving quickly, but to show ... Read More
Type III interferon in COVID-19: Protective or harmful?
Our immune system makes interferons and other cytokines to help us fight viruses. But in COVID-19, we’ve learned that they can also contribute to damaging, potentially life-threatening lung inflammation. New work published yesterday in the journal Science helps tease out the good from the bad for one interferon of interest: type III. Key takeaways. At ... Read More