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  • A new druggable cancer target: RNA-binding proteins on the cell surface

  • EarlyBird: Addressing dyslexia through game play

    This two-handed robot goes deep into the brain

    Could concussion be monitored through urine samples?

A bio-inspired approach to delivering local anesthetics

Research, Therapeutics/Diagnostics/Devices
Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and muscles, and are an attractive alternative to opioids. But injected by themselves, the anesthetics can easily float away, causing severe systemic toxicity. Encapsulating these drugs in ... Read More about A bio-inspired approach to delivering local anesthetics
Tagged: anesthesia, bioengineering, biomaterials and drug delivery, drug development, nanotechnology, pain
home saliva test that detects COVID-19 variants

Rapid saliva test detects COVID-19 variants, at home or point of care

Research, Therapeutics/Diagnostics/Devices
COVID-19 tests are now widely available, including FDA-approved tests like BinaxNOW that people can do at home. But none of the home tests — or any hospital test — can distinguish between specific SARS-CoV-2 variants. Detecting and tracking variants, essential for public health efforts, requires complete nucleic acid sequencing of the virus. Currently, only specialized ... Read More about Rapid saliva test detects COVID-19 variants, at home or point of care
Tagged: coronavirus, diagnostics, infectious diseases
expandable annuloplasty ring concept, inspired by Chinese finger traps

Inspired by Chinese finger traps, an annuloplasty ring that grows with the child

Specialty Care, Therapeutics/Diagnostics/Devices
This post is part of a series on innovations to treat valvular disease in children. Read our prior posts on transcatheter valve replacement and an expandable prosthetic heart valve. Prosthetic annuloplasty rings have improved the durability of heart valve repairs in adults. Implanted at the perimeter of dilated, leaky valves, they help keep the valve ... Read More about Inspired by Chinese finger traps, an annuloplasty ring that grows with the child
Tagged: cardiac surgery, heart, heart center, medical devices, research, surgery
adjustable airway stent concept

Soft stents, hardened in place by UV light, allow a snug, custom fit

Research, Therapeutics/Diagnostics/Devices
Airway stents are often used when the trachea and bronchi need to be buttressed, as in children and adults with tracheobronchomalacia whose airways become “floppy” and collapse during normal breathing. This condition can occur in conjunction with congenital cardiac anomalies in which the major heart vessels compress the trachea, and with severe, recurrent bronchitis. But ... Read More about Soft stents, hardened in place by UV light, allow a snug, custom fit
Tagged: bioengineering, cardiac research, congenital heart defect, medical devices, tracheomalacia
an illustration of a hand and arm with a wristband to detect seizures

Predicting pediatric seizures with a wristband: Study shows what’s possible

Research, Therapeutics/Diagnostics/Devices
The ability to track seizures has a number of potential benefits: It could allow physicians to better determine optimal dosing and timing of medication, as well as enable timely interventions to help prevent impending seizures. Traditionally, electroencephalography (EEG) and electrocorticography have been used to evaluate and forecast seizures. However, more compact, portable approaches — such ... Read More about Predicting pediatric seizures with a wristband: Study shows what’s possible
Tagged: epilepsy, research, seizures
a sonogram

Innovative new shunt delivery system holds promise for treatment of fetal urinary tract obstruction

Therapeutics/Diagnostics/Devices
Urinary tract obstruction that occurs in utero can have serious consequences for the fetus. Such obstructions can block the flow of fetal urine, which makes up amniotic fluid. Without adequate levels of amniotic fluid, a fetus may not develop properly, especially in terms of the fetal lungs. Fetal urinary tract obstructions can range from mild ... Read More about Innovative new shunt delivery system holds promise for treatment of fetal urinary tract obstruction
Tagged: fetal medicine, MFCC, urology

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