Archive for autism spectrum disorder
‘Mosaic’ gene mutations could explain some cases of autism
The causes of autism remain mysterious. Scientists have linked autism spectrum disorder to a long list of genes, but most children with autism have no known explanation. Two new studies add to the picture, implicating mutations that affect only a fraction of a child’s cells. Called mosaic mutations, they open a new avenue for research ... Read More
The tiny choroid plexus protects the prenatal brain — but may also pass on inflammation from the mother
Floating in fluid deep in the brain are small, little-understood fronds of tissue. Two new studies reveal that these miniature organs are a hotbed of immune system activity. This activity may protect the developing brain from infections and other insults — but may also contribute to neurodevelopmental disorders like autism. Key takeaway This pioneering work ... Read More
COVID-19 and IEPs: Education for children with special needs
When Massachusetts shut down its public schools to prevent the spread of COVID-19, educators faced a huge challenge. With little time to prepare, school districts had to redesign classroom lesson plans for close to a million students. The interrupted school year has been especially hard on kids with individualized education programs (IEPs). An IEP is ... Read More
Preparing your child with autism for a hospital visit during COVID-19
Most kids aren’t used to the sights, sounds, and smells of a hospital. And because of COVID-19, medical settings look and sound much different than usual. Busy hallways are nearly empty. People are wearing face masks. Even kids who come to the hospital often may not recognize the place they’ve visited many times. (Image: David ... Read More
CRUSH: Developing a sexual education program for young adults on the autism spectrum
For many young adults on the autism spectrum, developing and maintaining positive intimate relationships can be challenging. But collaboration between Boston Children’s Hospital and UMass Boston hopes to provide some on-point guidance through a new initiative¾the Competence in Romance and Sexual Health (CRUSH) program, aimed at developing a new sex education curriculum for young adults ... Read More
‘Face blindness’ may represent a failed brain network — and could shed light on autism
People with prosopagnosia, or “face blindness,” have trouble recognizing faces — even those of close friends and family members. While some people can compensate by using clothing and other cues, face blindness often creates serious social problems. It often becomes apparent in early childhood, but, rarely, people can acquire face blindness later in life after ... Read More
Exploring autism by way of three rare genetic disorders
Rajna Filip-Dhima, MS is a senior project manager for the Translational Neuroscience Center at Boston Children’s Hospital and for the Developmental Synaptopathies Consortium, which just received a new cycle of NIH funding. Autism spectrum disorder (ASD) is now believed to affect 1 in 59 children in the U.S. Over the past five years, Boston Children’s Hospital ... Read More
Talking about a child with special needs: Tips from a mom
Our two girls, Lily (age 8) and Elise (age 6), were both diagnosed with SYNGAP1 syndrome last year. At the time there were only 250 known cases of SYNGAP1 in the world. Yes, that means our girls are 2 out of 250. It is extremely rare, and even more rare to have two children with a de ... Read More
Babies’ EEG patterns predict whether they will develop autism
Signs of autism spectrum disorder (ASD) typically start to become apparent only in a child’s second year of life or later, but earlier identification could allow children to receive interventions as babies, when they have greater brain plasticity and thus may receive more benefit. A new study in Nature Communications finds that periodic EEGs in ... Read More
Pupil dilation and heart rate, analyzed by AI, may offer early autism diagnosis
Autism and other neurodevelopmental disorders often aren’t diagnosed until a child is a few years of age, when behavioral interventions and speech/occupational therapy become less effective. But new research this week in PNAS suggests that two simple, quantifiable measures — spontaneous fluctuations in pupil dilation or heart rate — could enable much earlier diagnosis of ... Read More