Archive for infectious diseases
Capturing SARS-CoV-2’s shape-shifting spike protein
The rod-like spike proteins on the surface of SARS CoV-2 are the tip of the spear of the COVID-19 pandemic. The spikes bind to human cells via the ACE2 receptor and then dramatically change shape. They jack-knife, folding in on themselves to fuse their own membrane with the membrane of our cells. And that opens ... Read More
Internet searches provide real-time estimate of Lyme disease risk
Lyme disease season is well underway. How much of a risk do we face for this tick-borne illness? A new method dubbed Lymelight, developed by researchers at Boston Children’s Hospital and Google, can accurately estimate Lyme disease risk in real time, down to the county level. Historically, estimates of Lyme disease have been based on ... Read More
More details on MIS-C, the post-COVID multi-system inflammatory syndrome in children
Boston Children’s Hospital and collaborators launched the national Overcoming COVID-19 in April to track children, teens, and young adults hospitalized with COVID-19 across the U.S. In yesterday’s New England Journal of Medicine, investigators provides a fuller picture of the still-mysterious, life-threatening multi-system inflammatory syndrome in children (MIS-C). Key takeaways· The largest case series of MIS-C ... Read More
EEE: A worried parent’s questions, answered
In the midst of the coronavirus outbreak, the last thing we want to think about is another virus. But now that summer is upon us, so are mosquitoes. And with mosquitoes comes the risk of eastern equine encephalitis (EEE), a rare but deadly virus. Last fall in Massachusetts, there were 12 confirmed cases of EEE, ... Read More
Getting to a COVID-19 vaccine as fast and as safely as possible
The novel coronavirus is not expected to disappear anytime soon. With physical distancing, virus testing, contact tracing, and potentially new therapeutics, we may be able to keep it partially at bay. But many eyes are looking toward a COVID-19 vaccine, and scientists are feeling the urgency. Key takeaways. Work is moving quickly, but to show ... Read More
Type III interferon in COVID-19: Protective or harmful?
Our immune system makes interferons and other cytokines to help us fight viruses. But in COVID-19, we’ve learned that they can also contribute to damaging, potentially life-threatening lung inflammation. New work published yesterday in the journal Science helps tease out the good from the bad for one interferon of interest: type III. Key takeaways. At ... Read More
Should you send your child to camp this summer?
Camp — or no camp — this summer? That’s the question facing many parents and caregivers right now as more businesses begin to reopen. The answer will be a very personal one for each family, depending on their specific circumstances and comfort level with risk. While some camps have already been cancelled due to coronavirus ... Read More
Treating inflammation in MIS-C: An evidence-based approach
Multisystem inflammatory syndrome in children (MIS-C) is a complex, post-COVID-19 spectrum of illness that has affected a small number of children and adolescents. Symptoms can include features of Kawasaki disease, cardiac dysfunction, hypotension and toxic-shock-like signs, abnormal blood coagulation, and prominent GI symptoms. At its core is a hyperinflammatory response that we do not yet ... Read More
Keeping up with childhood vaccines and screenings during the COVID-19 outbreak
Amid the coronavirus outbreak, many parents have been understandably hesitant to take their kids to their health care provider for routine health care, such as vaccines and health screenings. But pediatricians worry that this trend could open the door to outbreaks of other types of childhood illnesses, such as measles and whooping cough. We recently ... Read More
The polio outbreak of 1955: Lessons from an epidemic
“This is going to be a tough year.” Claire McCarthy was a young physical therapist in early March 1955 when orthopedic surgeon Dr. David Grice, made this observation. At the time, Boston Children’s Hospital was the receiving center for adults and children with polio in New England. The hospital typically saw an upsurge in cases ... Read More